Research

Highlighted

Global lysine methylome profiling using systematically characterized affinity reagents
Global lysine methylome profiling using systematically characterized affinity reagents
Christine A. Berryhill, Jocelyne N. Hanquier, Emma H. Doud, Eric Cordeiro-Spinetti, Bradley M. Dickson, Scott B. Rothbart, Amber L. Mosley, Evan M. Cornett
Scientific Reports  ·  07 Jan 2023  ·  doi:10.1038/s41598-022-27175-x
cornett lab mass spectrometry

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2024

Select EZH2 inhibitors enhance viral mimicry effects of DNMT inhibition through a mechanism involving NFAT:AP-1 signaling
Select EZH2 inhibitors enhance viral mimicry effects of DNMT inhibition through a mechanism involving NFAT:AP-1 signaling
Alison A. Chomiak, Rochelle L. Tiedemann, Yanqing Liu, Xiangqian Kong, Ying Cui, …, Kate E. Thurlow, Evan M. Cornett, Michael J. Topper, Stephen B. Baylin, Scott B. Rothbart
Science Advances  ·  29 Mar 2024  ·  doi:10.1126/sciadv.adk4423
collaboration VAI

2023

Identification of nonhistone substrates of the lysine methyltransferase PRDM9
Identification of nonhistone substrates of the lysine methyltransferase PRDM9
Jocelyne N. Hanquier, Kenidi Sanders, Christine A. Berryhill, Firoj K. Sahoo, Andy Hudmon, Jonah Z. Vilseck, Evan M. Cornett
Journal of Biological Chemistry  ·  01 May 2023  ·  doi:10.1016/j.jbc.2023.104651
cornett lab
Global lysine methylome profiling using systematically characterized affinity reagents
Global lysine methylome profiling using systematically characterized affinity reagents
Christine A. Berryhill, Jocelyne N. Hanquier, Emma H. Doud, Eric Cordeiro-Spinetti, Bradley M. Dickson, Scott B. Rothbart, Amber L. Mosley, Evan M. Cornett
Scientific Reports  ·  07 Jan 2023  ·  doi:10.1038/s41598-022-27175-x
cornett lab mass spectrometry

2022

Structural and genome-wide analyses suggest that transposon-derived protein SETMAR alters transcription and splicing
Structural and genome-wide analyses suggest that transposon-derived protein SETMAR alters transcription and splicing
Qiujia Chen, Alison M. Bates, Jocelyne N. Hanquier, Edward Simpson, Douglas B. Rusch, Ram Podicheti, Yunlong Liu, Ronald C. Wek, Evan M. Cornett, Millie M. Georgiadis
Journal of Biological Chemistry  ·  01 May 2022  ·  doi:10.1016/j.jbc.2022.101894

2020

A physical basis for quantitative ChIP-sequencing
A physical basis for quantitative ChIP-sequencing
Bradley M. Dickson, Rochelle L. Tiedemann, Alison A. Chomiak, Evan M. Cornett, Robert M. Vaughan, Scott B. Rothbart
Journal of Biological Chemistry  ·  01 Nov 2020  ·  doi:10.1074/jbc.RA120.015353
Click Chemistry-Based Two-Component System for Efficient Inhibition of Human Immunodeficiency Virus (HIV) Reverse Transcriptase (RT)
Click Chemistry-Based Two-Component System for Efficient Inhibition of Human Immunodeficiency Virus (HIV) Reverse Transcriptase (RT)
Carlos E. Ledezma, Evan M. Cornett, Dmitry M. Kolpashchikov
ACS Omega  ·  21 Feb 2020  ·  doi:10.1021/acsomega.9b03942

2019

A Read/Write Mechanism Connects p300 Bromodomain Function to H2A.Z Acetylation
A Read/Write Mechanism Connects p300 Bromodomain Function to H2A.Z Acetylation
Yolanda Colino-Sanguino, Evan M. Cornett, David Moulder, Grady C. Smith, Joel Hrit, …, Robert M. Vaughan, Krzysztof Krajewski, Scott B. Rothbart, Susan J. Clark, Fátima Valdés-Mora
iScience  ·  01 Nov 2019  ·  doi:10.1016/j.isci.2019.10.053
Lysine Methylation Regulators Moonlighting outside the Epigenome
Lysine Methylation Regulators Moonlighting outside the Epigenome
Evan M. Cornett, Laure Ferry, Pierre-Antoine Defossez, Scott B. Rothbart
Molecular Cell  ·  01 Sep 2019  ·  doi:10.1016/j.molcel.2019.08.026
Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF
Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF
Yi Zhang, Younghoon Jang, Ji-Eun Lee, JaeWoo Ahn, Longxia Xu, …, Brian D. Strahl, Scott B. Rothbart, Xiaobing Shi, Kai Ge, Tatiana G. Kutateladze
Nature Communications  ·  24 May 2019  ·  doi:10.1038/s41467-019-10324-8
evans postdoc papers VAI

2018

A DNA methylation reader complex that enhances gene transcription
A DNA methylation reader complex that enhances gene transcription
C. Jake Harris, Marion Scheibe, Somsakul Pop Wongpalee, Wanlu Liu, Evan M. Cornett, …, James A. Wohlschlegel, Jiamu Du, Scott B. Rothbart, Falk Butter, Steven E. Jacobsen
Science  ·  07 Dec 2018  ·  doi:10.1126/science.aar7854
evans postdoc papers VAI
A functional proteomics platform to reveal the sequence determinants of lysine methyltransferase substrate selectivity
A functional proteomics platform to reveal the sequence determinants of lysine methyltransferase substrate selectivity
Evan M. Cornett, Bradley M. Dickson, Krzysztof Krajewski, Nicholas Spellmon, Andrew Umstead, …, Joseph Brunzelle, Zhe Yang, Irving E. Vega, Zu-Wen Sun, Scott B. Rothbart
Science Advances  ·  02 Nov 2018  ·  doi:10.1126/sciadv.aav2623
KOPL evans postdoc papers VAI
Examining the Roles of H3K4 Methylation States with Systematically Characterized Antibodies
Examining the Roles of H3K4 Methylation States with Systematically Characterized Antibodies
Rohan N. Shah, Adrian T. Grzybowski, Evan M. Cornett, Andrea L. Johnstone, Bradley M. Dickson, …, Neha Arora, Zu-Wen Sun, Scott B. Rothbart, Michael-Christopher Keogh, Alexander J. Ruthenburg
Molecular Cell  ·  01 Oct 2018  ·  doi:10.1016/j.molcel.2018.08.015
evans postdoc papers VAI
Chromatin structure and its chemical modifications regulate the ubiquitin ligase substrate selectivity of UHRF1
Chromatin structure and its chemical modifications regulate the ubiquitin ligase substrate selectivity of UHRF1
Robert M. Vaughan, Bradley M. Dickson, Matthew F. Whelihan, Andrea L. Johnstone, Evan M. Cornett, Marcus A. Cheek, Christine A. Ausherman, Martis W. Cowles, Zu-Wen Sun, Scott B. Rothbart
Proceedings of the National Academy of Sciences  ·  13 Aug 2018  ·  doi:10.1073/pnas.1806373115
evans postdoc papers VAI
Comparative biochemical analysis of UHRF proteins reveals molecular mechanisms that uncouple UHRF2 from DNA methylation maintenance
Comparative biochemical analysis of UHRF proteins reveals molecular mechanisms that uncouple UHRF2 from DNA methylation maintenance
Robert M Vaughan, Bradley M Dickson, Evan M Cornett, Joseph S Harrison, Brian Kuhlman, Scott B Rothbart
Nucleic Acids Research  ·  28 Feb 2018  ·  doi:10.1093/nar/gky151
evans postdoc papers VAI

2017

Analysis of Histone Antibody Specificity with Peptide Microarrays
Analysis of Histone Antibody Specificity with Peptide Microarrays
Evan M. Cornett, Bradley M. Dickson, Scott B. Rothbart
Journal of Visualized Experiments  ·  01 Aug 2017  ·  doi:10.3791/55912
evans postdoc papers VAI

2016

Systematic comparison of monoclonal versus polyclonal antibodies for mapping histone modifications by ChIP-seq
Systematic comparison of monoclonal versus polyclonal antibodies for mapping histone modifications by ChIP-seq
Michele Busby, Catherine Xue, Catherine Li, Yossi Farjoun, Elizabeth Gienger, …, Charles B. Epstein, Evan M. Cornett, Scott B. Rothbart, Chad Nusbaum, Alon Goren
Epigenetics & Chromatin  ·  04 Nov 2016  ·  doi:10.1186/s13072-016-0100-6
Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1
Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1
Joseph S Harrison, Evan M Cornett, Dennis Goldfarb, Paul A DaRosa, Zimeng M Li, …, Rachel E Klevit, Krzysztof Krajewski, Brian Kuhlman, Brian D Strahl, Scott B Rothbart
eLife  ·  06 Sep 2016  ·  doi:10.7554/eLife.17101
Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase
Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase
Forest H. Andrews, Qiong Tong, Kelly D. Sullivan, Evan M. Cornett, Yi Zhang, …, Brian D. Strahl, James C. Costello, Joaquin M. Espinosa, Scott B. Rothbart, Tatiana G. Kutateladze
Cell Reports  ·  01 Sep 2016  ·  doi:10.1016/j.celrep.2016.08.050
Substrate Specificity Profiling of Histone-Modifying Enzymes by Peptide Microarray
Substrate Specificity Profiling of Histone-Modifying Enzymes by Peptide Microarray
E.M. Cornett, B.M. Dickson, R.M. Vaughan, S. Krishnan, R.C. Trievel, B.D. Strahl, S.B. Rothbart
Methods in Enzymology  ·  01 Jan 2016  ·  doi:10.1016/bs.mie.2016.01.008
ArrayNinja
ArrayNinja
B.M. Dickson, E.M. Cornett, Z. Ramjan, S.B. Rothbart
Methods in Enzymology  ·  01 Jan 2016  ·  doi:10.1016/bs.mie.2016.02.002

2015

Nuclease-containing media for resettable operation of DNA logic gates
Nuclease-containing media for resettable operation of DNA logic gates
Martin R. O’Steen, Evan M. Cornett, Dmitry M. Kolpashchikov
Chemical Communications  ·  01 Jan 2015  ·  doi:10.1039/c4cc09283j

2013

Deoxyribozyme Cascade for Visual Detection of Bacterial RNA
Deoxyribozyme Cascade for Visual Detection of Bacterial RNA
Yulia V. Gerasimova, Evan M. Cornett, Emily Edwards, Xiaoli Su, Kyle H. Rohde, Dmitry M. Kolpashchikov
ChemBioChem  ·  17 Sep 2013  ·  doi:10.1002/cbic.201300471
Two-component covalent inhibitor
Two-component covalent inhibitor
Evan M. Cornett, Yulia V. Gerasimova, Dmitry M. Kolpashchikov
Bioorganic & Medicinal Chemistry  ·  01 Apr 2013  ·  doi:10.1016/j.bmc.2013.01.021
Operating Cooperatively (OC) Sensor for Highly Specific Recognition of Nucleic Acids
Operating Cooperatively (OC) Sensor for Highly Specific Recognition of Nucleic Acids
Evan M. Cornett, Martin R. O’Steen, Dmitry M. Kolpashchikov
PLoS ONE  ·  18 Feb 2013  ·  doi:10.1371/journal.pone.0055919
SNP Analysis Using a Molecular Beacon-Based Operating Cooperatively (OC) Sensor
SNP Analysis Using a Molecular Beacon-Based Operating Cooperatively (OC) Sensor
Evan M. Cornett, Dmitry M. Kolpashchikov
Methods in Molecular Biology  ·  01 Jan 2013  ·  doi:10.1007/978-1-62703-535-4_6

2012

Molecular Logic Gates for DNA Analysis: Detection of Rifampin Resistance in <i>M. tuberculosis</i> DNA
Molecular Logic Gates for DNA Analysis: Detection of Rifampin Resistance in M. tuberculosis DNA
Evan M. Cornett, Eleanor A. Campbell, George Gulenay, Evan Peterson, Neha Bhaskar, Dmitry M. Kolpashchikov
Angewandte Chemie International Edition  ·  09 Aug 2012  ·  doi:10.1002/anie.201203708

2010

RNA‐Cleaving Deoxyribozyme Sensor for Nucleic Acid Analysis: The Limit of Detection
RNA‐Cleaving Deoxyribozyme Sensor for Nucleic Acid Analysis: The Limit of Detection
Yulia V. Gerasimova, Evan Cornett, Dmitry M. Kolpashchikov
ChemBioChem  ·  01 Apr 2010  ·  doi:10.1002/cbic.201000006